• February 2007: Project Art for health
    At the conference the paintings of the project Art for health will be shown (...)

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Programme

Thursday, December 13, 2007

05:00 pm

Opening Ceremony

Chairs : P. Miotti, F. Dabis
Welcome addresses
J.E. Touze, Directeur de l’Ecole d’Application des Armées du Val de Grâce
E. Menu, G. Scarlatti, D. Béquet, chairs of the conference
05:15 pm Introductory lecture Great challenges to PMTCT in the South : The role of the developped nations in supporting strategies that work
D.Onyango (KN)
05:45 pm

Session 1a : Viral and maternal determinants of mother to child transmission (MTCT) of chronic viral infections

Chairs : A. Ayouba, C. Davrinche
Keynote Lecture : Virologic and host determinants of breastfeeding transmission of human retroviruses
P. Van de Perre (F)
6:15-7:15 pm
6:15 pm Primary HIV-1 infection during pregnancy : high rate of HIV-1 MTCT in a cohort of patients in southern Brazil
Nielsen-Saines K., Melo M., Varella I., Fonseca R., Lira R., Turella M.L., Canti I., Campello C., Moreira A.M., Riegel Santos B
6:30 pmRole of R5 phenotypic variation in mother-to-child transmission of HIV-1
Cavarelli M., Karlsson I., Zanchetta M., Antonsson L., Plebani A., Giaquinto C., Fenyo E.M., De Rossi A., Scarlatti G.
6:45 pm Bile-salt stimulated lipase in human milk binds DC-SIGN and inhibits HIV-1 transmission
Stax M., Naarding M., Speijer D., Hernell O., Pollakis G., Paxton W.
7:00 pm Human herpesvirus 8 (HHV-8) " in vitro" infection of human placental histocultures
Di Stefano M., Menu E., Gesualdo L., Greco P., Chieco-Bianchi L., Barbierato M., Cantatore S., di Gangi I.M., Calabre M.L., Fiore J.R.
7:15 pm HIV-1 internalization in polarized human trophoblasts occurs through a peculiar endocytic pathway
Tremblay M.J., Vidricaire G.
7:30 pm WELCOME RECEPTION

Friday, December 14, 2007

09:00 am

Session 1b : Viral and maternal determinants of mother to child transmission (MTCT) of chronic viral infections

Chairs : G. Biberfeld, G. Chaouat
Keynote Lecture : Determinants of maternal infection associated with virus infection of the fetus and newborn infant
W. Britt (USA)
09:00-10:30 am
9:30 amA major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27
Plancoulaine S., Gessain A., Tortevoye P., Boland-Auge A., Vasilescu A., Matsuda F., Abel L.
9:45 amInfluence of pregnancy on the specificity and breadth of antigen recognition by HIV-specific cytotoxic T lymphocytes
Jolette E., Samson J., Lapointe N., Boucher M., Soudeyns H.
10:00 amHCV-Specific T-cell Responses during Acute Hepatitis C Virus Infection in Pregnancy
Honegger J., Prasad M., Colombo D., Bowen D., Walker C.
10:15 amToxoplasmosis reactivation following HAART introduction associated with foetal death in a severely immune suppressed HIV-infected woman : An Immune reconstitution inflammatory syndrome (IRIS) consequence ?
Caby F., Lemercier D., Touafek L., Paris L., Gonzalez M., Carcelain G., Pauchard M., Canestri A., Dommergues M., Tubiana R.
10:30-11:00 am Coffee break and poster viewing
11:00am

Session 2 : Role of co-infections in MTCT

Chairs : L. Pembrey, P. Msellati
Keynote Lecture : Mechanisms by which co-infections modify HIV-1 transmission
G. John-Stewart (USA)
11:30 am-12:45 pm 
11:30 amHigh prevalence of cytomegalovirus (CMV) infection in infants born to HIV infected mothers–ANRS French Perinatal Cohort (EPF)
Guibert G., Leruez-Ville M., Rouzioux C., Tubiana R., Mandelbrot L., Blanche S., Teglas J.P., BenMebarek Y., Le Chenadec J., Warszawski J., ANRS French Perinatal Cohort (EPF)
11:45 amHepatitis C virus quasispecies evolution during pregnancy and between consecutive pregnancies : influence of maternal immune responses
Troesch M., Meunier I., Lepage C., Samson J., Lapointe N., Boucher M., Soudeyns H.
12:00 pmRisk factors for Human Cytomegalovirus (HCMV) infection in infants born to HIV-1 infected mothers in Thailand
Khamduang W., Sirirungsi W., Lallemant M., Ardong W., Hinjiranandana T., Sirinontakan S., Somsamai R., Pagdi K., McIntosh K., Leurent B., Jourdain G., Ngo-Giang-Huong N.
12:15 pmCo-infection with Trypanosoma cruzi (Chagas´ disease agent) decreases HIV-1 transcription in human placenta.
Dolcini G., Solana M.E., Andreani G., Celentano A.M., Donato A.M., Del Rio A., Martinez Peralta L.
12:30 pmPlasmodium falciparum and placental cytokine profiles among pregnant women in relation to their HIV-1 status : possible implications for mother-to-child transmission (MTCT) of HIV-1 in Cameroon
Kfutwah A., Mary J.Y., Lemen B., Leke R., Rousset D., Barré-Sinoussi F., Nerrienet E., Menu E., Ayouba A. for The ANRS 1267 Study Team
12:45-2:00 pm Lunch and posters viewing
2:00 pm

Session 3 : Prevention and control of MTCT : from antivirals through immunotherapy and vaccine

Chairs : M. Marthas, D.K. Ekouevi
Keynote Lecture : Mother-to-Child Transmission of Persistent Viral Infections : Pathogenesis and Prevention
K. Luzuriaga (USA)
02:30 - 4:00 pm
2:30 pmVSV/MVA vaccine rapidly elicits SIV antibodies and local & systemic SIV T cell responses in macaque neonates but does not prevent SIV dissemination after oral challenge
Abel K., Van Rompay K.K., Eastlick J., Moore J., Lemieux M., Schmidt K., Earl P., Buonocore-Buzzelli L., Moss B., Rose N., Rose J., McChesney M.B., Kozlowski P., Marthas M.L.
2:45 pmPrevention of mother-to-child HIV transmission in France : is access to care different for women from sub-Saharan Africa than for French women ?
Jasseron C., Warszawski J., Blanche S., Rouzioux C., Le Chenadec J., Dolfus C., Faye A., Hamrene K., Teglas J.P., Tubiana R., Mandelbrot L., ANRS French Perinatal Cohort (EPF)
3:00 pmPrevention of mother-to-child transmission of HIV-1 through breastfeeding by treating infants or mothers prophylactically with antiretrovirals in Dar es Salaam, Tanzania. The MITRA and MITRA PLUS studies
Kilewo C., Mhalu F., Swai A., Msemo G., Lipyoga R., Lyamuya E., Massawe A., Ngarina M., Karlsson K., Biberfeld G.
3:15 pmPrevalence of HIV-1 drug resistance mutations in antiretroviral naïve pregnant women from Cambodia, Cameroon, Central African Republic and Vietnam
Ayouba A., for the FSP/RAI/ARV Study Team
3:30 pmLow birth weight is associated with maternal Nevirapine based antiretroviral therapy in Abidjan, Côte d’Ivoire : The Ditrame Plus project and MTCT-Plus initiative (2001-2007)
Ekouevi D., Coffie P.
3:45 pmTolerance and Viral Resistance After Short Course of Tenofovir Disoproxil Fumarate (TDF) and Emtricitabine (FTC) to Prevent Mother-to-Child Transmission (PMTCT) of HIV-1 : the TEmAA ANRS 12109 Phase II Trial, Step 1
Arrivé E., Blanche S., Chaix M.L., Nerrienet E., Rouzioux C., McIntyre J., Grey G., Coffié P., Kruy Sim L., Ekouévi D., Dabis F.
04:00-4:30 pm Coffee break and poster viewing
04:30 pm

Session 4 : Immunological development and host defences in neonates and children

Chairs : M. Morgado, P. Rossi
Keynote Lecture : Neonatal adaptation of the immune system
P. Brandtzaeg (N)
05:00–5:45 pm
5:00 pmMicrotransfusion and viral exposure in uninfected infants born to HIV-infected women
Warning J., Ziegler J., French R.
5:15 pmFrequency of HIV-specific CD8 T lymphocytes is inversely correlated to HIV DNA levels in untreated infected children
Buseyne F., Blanche S., Burgard M., Milliancourt C., Scott_Algara D., Rouzioux C., Rivière Y.
5:30 pmPrimary CMV infection : a co-factor for HIV-1 disease progression in African infants ?
Slyker J.
EVENING 6:15 Concert & Painting private show

Saturday, December 15, 2007

09:00 am

Session 5 : Diagnosis, monitoring and treatment of infected children

Chairs : E. Nerrienet, N. Ngo-Giang-Huong
Keynote Lecture : Natural history of vertically acquired HCV infection
P.A. Tovo (I)
09:30-10:30 am
9:30 amEarly diagnosis of HIV-1 infection in newborns, in the context of prevention of mother-to-child transmission with HAART (Perinatal Cohort ANRS Co 01)
Avettand-Fenoel V., Chaix M.L., Blanche S., Burgard M., Warszawski J., Rouzioux C.
9:45 amEarly versus deferred highly active antiretroviral therapy in HIV infected infants : a European collaborative cohort study
Goetghebuer T., Haelterman E., Hainaut M., Warszawski J., Le Chenadec J., Dollfus C., Gibb D.M., Giaquinto C., Levy J. for the European Infant Collaboration Group
10:00 amOnce-a-day pediatric HAART with DDI+3TC+EFV in Burkina Faso. A phase II Trial (ANRS 12103 trial)
Msellati P., Nacro B., Nicolas J., Mathieu O., Peyrière H., Yaméogo S., Drabo A., Ouiminga A., Diagbouga S., Rouet F., Tamboura H., Hien H., Zoure E., Van de Perre P.
10:15 amEarly virological suppression despite high frequency NNRTI resistance following perinatal prophylaxis in HIV-infected African infants
Prendergast A., Mphatswe W., Tudor-Williams G., Blanckenberg N., Cengimbo A., Jeena P., Rakgotho M., Pillay V., Thobakgale C., Reddy S., Mncube Z., Vanderstok M., McCarthy N., Dong C., Coovadia H., Morris L., Walker B.D., Goulder P.
10:30 amVirus phenotype variability during disease progression of HIV-1 infected children
Dispinseri S., Cavarelli M., Ripamonti C., Karlsson I., Antonsson L., Plebani A., Fenyo E.M., Scarlatti G.
10:30-11:00 am Coffee break and poster viewing
11:00 am Closing ceremony
Chairs : S. Blanche, C. Rouzioux,
Concluding remarks : F. Barré-Sinoussi
Memorial lecture : Main infections in the children in developing countries : reports and perspectives
C. Courpotin (F)
Welcome to the DDIC 2008 S. Blanche, C. Rouzioux
12:00 pm Closing of the conference :G. Scarlatti, E. Menu